Covered by Medicare for Select Indications

Signatera^™

Transforming the management of cancer with personalized testing

Signatera™ is a highly sensitive and personalized molecular residual disease assay (MRD) using circulating tumor DNA (ctDNA), custom designed for each patient to help identify relapse earlier than standard of care tools.

Signatera™ Indications

Signatera™ can be used for a variety of cancer types. To learn more about how, please select one.

Select a cancer type:

Signatera™ Indications

Signatera™ can be used for a variety of cancer types. To learn more about how, please select one below:

For Clinicians

When to use Signatera™ MRD test?

Neoadjuvant Setting

To assess response to neoadjuvant therapy to help inform next steps

Adjuvant Setting

Use after surgery to evaluate the need for adjuvant chemotherapy and inform when to escalate or right-size treatment

Surveillance Setting

Detect MRD with greater sensitivity than current standard of care tools
Signatera™ is meant to be used serially to detect relapse earlier

Not all MRD assays are created equal

Considerations when choosing patient monitoring tools:

Comprehensive clinical validation

Demonstrated real-world experience

Personalized and tumor-informed

Extensively validated

Signatera™ has been validated in >100 peer-reviewed publications studying >30,000 patients across >30 tumor types^1-6

Deep experience

Signatera™ has been used to manage over 250,000 patients and has been ordered by more than 40% of US oncologists⁶

Covered by Medicare for multiple solid tumor indications

Stage II-IV and oligometastatic colorectal cancer (CRC) in the adjuvant and recurrence monitoring settings

Stage II-IV breast cancer in the neoadjuvant setting, regardless of subtype Stage IIb and higher breast cancer in the adjuvant and recurrence monitoring settings

Muscle invasive bladder cancer (MIBC) in the adjuvant and recurrence monitoring settings

Stage II-IV ovarian, fallopian tube, or primary peritoneal cancer in the adjuvant and recurrence monitoring settings

For monitoring of response to immune-checkpoint inhibitor (ICI) therapy for patients with any solid tumor

Is Signatera™ right for your patients?

We’re here to help you find out

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References

¹Reinert T, Henriksen TV, Christensen E, et al. JAMA Oncol. 2019. doi:10.1001/jamaoncol.2019.0528.

²Coombes RC, et al., Clin Cancer Res, 2019.

³Lebow, et al., Front. Oncol, 2023.

⁴Christensen E, et al. J Clin Oncol, 2019.

⁵Kotani D. et al, Nature Medicine, 2023.

⁶Data on file

Signatera™

Transforming the management of cancer with personalized testing

Signatera™ Indications

When to use Signatera™ MRD test?

Neoadjuvant Setting

Adjuvant Setting

Surveillance Setting

Not all MRD assays are created equal

Considerations when choosing patient monitoring tools:

Covered by Medicare for multiple solid tumor indications

Find out more about the Signatera™ test for MRD

Is Signatera™ right for your patients?

We’re here to help you find out

Natera would like to send you information about our products and services. You may unsubscribe from these communications at any time. By submitting your information you are agreeing to Natera's terms of use and privacy policy.

Signatera^™